首页>>文献首页>>文献正文

Disruption of PAMP-Induced MAP Kinase Cascade by a Pseudomonas syringae Effector Activates Plant Immunity Mediated by the NB-LRR Protein SUMM2

renchunxiao 添加于 2012/3/21 15:10:40  1182次阅读 | 0次推荐 | 0个评论

Pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) serves as a primary plant defense response against microbial pathogens, with MEKK1, MKK1/MKK2, and MPK4 functioning as a MAP kinase cascade downstream of PAMP receptors. Plant Resistance (R) proteins sense specific pathogen effectors to initiate a second defense mechanism, termed effector-triggered immunity (ETI). In a screen for suppressors of the mkk1 mkk2 autoimmune phenotype, we identify the nucleotide-binding leucine-rich repeat (NB-LRR) protein SUMM2 and find that the MEKK1-MKK1/MKK2-MPK4 cascade negatively regulates SUMM2-mediated immunity. Further, the MEKK1-MKK1/MKK2-MPK4 cascade positively regulates basal defense targeted by the Pseudomonas syringae pathogenic effector HopAI1, which inhibits MPK4 kinase activity. Inactivation of MPK4 by HopAI1 results in activation of SUMM2-mediated defense responses. Our data suggest that SUMM2 is an R protein that becomes active when the MEKK1-MKK1/MKK2-MPK4 cascade is disrupted by pathogens, supporting the hypothesis that R proteins evolved to protect plants when microbial effectors suppress basal resistance

作 者:Zhibin Zhang, Yaling Wu, Minghui Gao, Jie Zhang, Qing Kong, Yanan Liu, Hongping Ba, Jianmin Zhou, Yuelin Zhang
期刊名称: cell host and micrbe
期卷页: 第卷 第期 页
学科领域:生命科学 » 细胞生物学 » 细胞、亚细胞结构与功能
添加人是否为作者:
原文链接:http://www.cell.com/cell-host-microbe/abstract/S1931-3128(12)00057-1
DOI:
ISBN:
关键词:
相关报道: http://paper.sciencenet.cn/htmlpaper/201232115152478223143.shtm
备 注:
文献笔记

   
导出选项:

评论 (0 个评论)

Page 1 of 1
<<<[1]>>>

举报 | Archiver | 科学网( 京ICP备07017567 )

GMT+8, 2011-2-15 11:31

Powered by ScienceNet.cn

Copyright © 2007- 科学时报社