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Original InvestigationPropranolol reduces implicit negative racial bias

renchunxiao 添加于 2012/3/16 10:58:33  1016次阅读 | 0次推荐 | 0个评论

Background Implicit negative attitudes towards other races are important in certain kinds of prejudicial social behaviour. Emotionalmechanisms are thought to be involved in mediating implicit outgroup bias but there is little evidence concerning the underlyingneurobiology. The aim of the present study was to examine the role of noradrenergic mechanisms in the generation of implicitracial attitudes.Methods Healthy volunteers (n=36) of white ethnic origin, received a single oral dose of the -adrenoceptor antagonist, propranolol (40 mg), in a randomised,double-blind, parallel group, placebo-controlled, design. Participants completed an explicit measure of prejudice and theracial implicit association test (IAT), 12 h after propranolol administration.Results Relative to placebo, propranolol significantly lowered heart rate and abolished implicit racial bias, without affecting themeasure of explicit racial prejudice. Propranolol did not affect subjective mood.Conclusions Our results indicate that -adrenoceptors play a role in the expression of implicit racial attitudes suggesting that noradrenaline-relatedemotional mechanisms may mediate negative racial bias. Our findings may also have practical importance given that propranololis a widely used drug. However, further studies will be needed to examine whether a similar effect can be demonstrated inthe course of clinical treatment.

作 者:Sylvia Terbeck, Guy Kahane, Sarah McTavish, Julian Savulescu, Philip J. Cowen and Miles Hewstone
期刊名称: Psychopharmacology
期卷页: 第卷 第期 页
学科领域:医学科学 » 中西医结合 » 中医药学研究新技术和新方法
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原文链接:http://www.springerlink.com/content/63v2561264075373/
DOI: 10.1007/s00213-012-2657-5
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相关报道: http://paper.sciencenet.cn/htmlpaper/20123161102510823016.shtm
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