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Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis

meijin 添加于 2012/2/26 17:57:00  1323次阅读 | 0次推荐 | 0个评论

The prevalence of avian H5N1 influenza A infections in humans has not been definitively determined. Cases of H5N1 infection in humans confirmed by the World Health Organization (WHO) are fewer than 600 in number, with an overall case fatality rate of >50%. We hypothesize that the stringent criteria for confirmation of a human case of H5N1 by WHO does not account for a majority of infections, but rather, the select few hospitalized cases that are more likely to be severe and result in poor clinical outcome. Meta-analysis shows that 1 to 2% of more than 12,500 study participants from 20 studies had seroevidence for prior H5N1 infection.

作 者:Wang, Taia T.; Parides, Michael K.; Palese, Peter
期刊名称: Science
期卷页: 第卷 第期 ~页
学科领域:医学科学 » 医学病原微生物与感染 » 病原细菌、细菌感染与宿主免疫
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原文链接:http://www.sciencemag.org/content/early/2012/02/22/science.1218888
DOI: 10.1126/science.1218888
ISBN: 0036-8075
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相关报道: http://paper.sciencenet.cn/htmlpaper/201222617585389622625.shtm
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