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MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome

dankan 添加于 2011/5/9 16:37:05  1552次阅读 | 0次推荐 | 0个评论

SummaryPrecise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria.

作 者:Yolanda Camara, Jorge Asin-Cayuela, Chan Bae Park, Metodi D. Metodiev, Yonghong Shi, Benedetta Ruzzenente, Christian Kukat, Bianca Habermann, Rolf Wibom, Kjell Hultenby, Thomas Franz, Hediye Erdjument-Bromage, Paul Tempst, B. Martin Hallberg, Claes M. Gustafsson, and Nils-Goran Larsson
期刊名称: Cell metabolism
期卷页: 4 May 2011 第 13卷 第 5期 527-539页
学科领域:生命科学 » 细胞生物学 » 细胞增殖、生长与分化
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原文链接:http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7MFH-52SC6VB-G&_user=10&_coverDate=05%2F04%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=8d4123edda7181c
DOI: 10.1016/j.cmet.2011.04.002
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相关报道: http://paper.sciencenet.cn/htmlpaper/2011591638668016678.shtm
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