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Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network

renchunxiao 添加于 2011/11/23 14:29:41  1379次阅读 | 0次推荐 | 1个评论

Whether hESC-derived neurons can fully integrate with and functionally regulate an existing neural network remains unknown. Here, we demonstrate that hESC-derived neurons receive unitary postsynaptic currents both in vitro and in vivo and adopt the rhythmic firing behavior of mouse cortical networks via synaptic integration. Optical stimulation of hESC-derived neurons expressing Channelrhodopsin-2 elicited both inhibitory and excitatory postsynaptic currents and triggered network bursting in mouse neurons. Furthermore, light stimulation of hESC-derived neurons transplanted to the hippocampus of adult mice triggered postsynaptic currents in host pyramidal neurons in acute slice preparations. Thus, hESC-derived neurons can participate in and modulate neural network activity through functional synaptic integration, suggesting they are capable of contributing to neural network information processing both in vitro and in vivo.

作 者:Weick, Jason P.; Liu, Yan; Zhang, Su-Chun
期刊名称: Proceedings of the National Academy of Sciences
期卷页: 第卷 第期 ~页
学科领域:生命科学 » 细胞生物学 » 细胞生物学研究中的新方法
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原文链接:http://www.pnas.org/content/early/2011/11/14/1108487108.abstract?sid=bb98c7d3-2c1c-4c08-be8e-10c62d0fe759
DOI: 10.1073/pnas.1108487108
ISBN: 0027-8424
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发表评论人:Muzhushanren [2011/11/25 2:50:46] 
very interesting
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