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Biomimetic self-templating supramolecular structures

meijin 添加于 2011/10/25 14:08:42  2486次阅读 | 0次推荐 | 0个评论

In nature, helical macromolecules such as collagen, chitin and cellulose are critical to the morphogenesis and functionality of various hierarchically structured materials1, 2, 3. During tissue formation, these chiral macromolecules are secreted and undergo self-templating assembly, a process whereby multiple kinetic factors influence the assembly of the incoming building blocks to produce non-equilibrium structures1, 4. A single macromolecule can form diverse functional structures when self-templated under different conditions. Collagen type I, for instance, forms transparent corneal tissues from orthogonally aligned nematic fibres5, distinctively coloured skin tissues from cholesteric phase fibre bundles6, 7, and mineralized tissues from hierarchically organized fibres8. Nature’s self-templated materials surpass the functional and structural complexity achievable by current top-down and bottom-up fabrication methods9, 10, 11, 12. However, self-templating has not been thoroughly explored for engineering synthetic materials. Here we demonstrate the biomimetic, self-templating assembly of chiral colloidal particles (M13 phage) into functional materials. A single-step process produces long-range-ordered, supramolecular films showing multiple levels of hierarchical organization and helical twist. Three distinct supramolecular structures are created by this approach: nematic orthogonal twists, cholesteric helical ribbons and smectic helicolidal nanofilaments. Both chiral liquid crystalline phase transitions and competing interfacial forces at the interface are found to be critical factors in determining the morphology of the templated structures during assembly. The resulting materials show distinctive optical and photonic properties, functioning as chiral reflector/filters and structural colour matrices. In addition, M13 phages with genetically incorporated bioactive peptide ligands direct both soft and hard tissue growth in a hierarchically organized manner. Our assembly approach provides insight into the complexities of hierarchical assembly in nature and could be expanded to other chiral molecules to engineer sophisticated functional helical-twisted structures.

作 者:Woo-Jae Chung,1, 2 Jin-Woo Oh,1, 2 Kyungwon Kwak,1, 2 Byung Yang Lee,1, 2 Joel Meyer,2 Eddie Wang,1, 2 Alexander Hexemer3 & Seung-Wuk Lee1, 2
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学科领域:工程材料 » 有机高分子材料 » 生物医用高分子材料
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原文链接:http://www.nature.com/nature/journal/v478/n7369/full/nature10513.html
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