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Classic Selective Sweeps Were Rare in Recent Human Evolution

iamahappyann 添加于 2011/3/11 11:16:11  2506次阅读 | 2次推荐 | 5个评论

Efforts to identify the genetic basis of human adaptations from polymorphism data have sought footprints of “classic selective sweeps” (in which a beneficial mutation arises and rapidly fixes in the population). Yet it remains unknown whether this form of natural selection was common in our evolution. We examined the evidence for classic sweeps in resequencing data from 179 human genomes. As expected under a recurrent-sweep model, we found that diversity levels decrease near exons and conserved noncoding regions. In contrast to expectation, however, the trough in diversity around human-specific amino acid substitutions is no more pronounced than around synonymous substitutions. Moreover, relative to the genome background, amino acid and putative regulatory sites are not significantly enriched in alleles that are highly differentiated between populations. These findings indicate that classic sweeps were not a dominant mode of human adaptation over the past ~250,000 years.

作 者:Ryan D. Hernandez, Joanna L. Kelley, Eyal Elyashiv, S. Cord Melton, Adam Auton, Gilean McVean, 1000 Genomes Project, Guy Sella, Molly Przeworski
期刊名称: Science
期卷页: 2011 第卷 第期 页
学科领域:生命科学 » 遗传学与生物信息学 »
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原文链接:http://www.sciencemag.org/content/331/6019/920.abstract
DOI: 10.1126/science.1198878
ISBN:
关键词: selction sweep, population polymorphism, evolution
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文献笔记

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Classic selective sweeps was considered as the main force of the polymorphism and adaptation of human populations. There are also many evidences to support this model. However, in this report, whe the research used 1000 human genome project data to detect the efforts of selctive sweeps on population genome, they found 1)diversity levels decrease near exons and conserved noncoding regions;2)the trough in diversity around human-specific amino acid substitutions is no more pronounced than around synonymous substitutions; 3)relative to the genome background, amino acid and putative regulatory sites are not significantly enriched in alleles that are highly differentiated between populations.

 
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