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Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study

wenjie99 添加于 2011/9/1 10:57:14  1658次阅读 | 0次推荐 | 0个评论

Aims Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis. Methods and results Cohort study of the entire Danish population followed from 1997 to 2006 by individual-level-linkage of nationwide prospectively recorded registers. Multivariable Poisson's regression and sensitivity analyses were used to assess the psoriasis-related risk of AF and ischaemic stroke. A total of 36 765 patients with mild psoriasis and 2793 with severe psoriasis were compared with 4 478 926 individuals, i.e. the reference population. In patients with mild psoriasis, the adjusted rate ratios (RRs) for AF were 1.50 (1.21–1.86) and 1.16 (1.08–1.24) in patients aged <50 and ≥50 years, respectively. Patients with severe psoriasis had a higher risk of AF with RRs 2.98 (1.80–4.92) in patients aged <50 years and 1.29 (1.01–1.65) in patients aged ≥50 years. Patients with psoriasis also demonstrated a disease severity-dependent increased risk of ischaemic stroke, i.e. RRs 1.97 (1.66–2.34) and 2.80 (1.81–4.34) in patients aged <50 years with mild and severe psoriasis, and RRs 1.13 (1.04–1.21) and 1.34 (1.04–1.71) in patients aged ≥50 years with mild and severe psoriasis, respectively. A range of sensitivity analyses yielded comparable results. Conclusion Psoriasis is associated with increased risk of AF and ischaemic stroke. These novel results add to a growing body of evidence, suggesting that patients with psoriasis could be considered at increased cardiovascular risk.

作 者:Ole Ahlehoff1,2,*, Gunnar H. Gislason1, Casper H. Jørgensen, Jesper Lindhardsen1, Mette Charlot1, Jonas B. Olesen1, Steen Z. Abildstrøm1, Lone Skov1, Christian Torp-Pedersen1 and Peter Riis Hansen1
期刊名称: Eur Heart J
期卷页: August 12, 2011 第卷 第期 页
学科领域:医学科学 » 皮肤及其附属器 » 皮肤免疫性疾病
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原文链接:http://eurheartj.oxfordjournals.org/content/early/2011/08/12/eurheartj.ehr285.abstract
DOI: 10.1093/eurheartj/ehr285
ISBN:
关键词: Atrial fibrillation, Ischaemic stroke, Psoriasis, Inflammation, Cardiovascular risk, Epidemiology
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