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Structure determination of two new C21 steroidal glycosides from Cynanchum komarovii

luohanguo 添加于 2017/11/27 11:32:51  77次阅读 | 0次推荐 | 0个评论

Two new 13,14:14,15-disecopregnane-type C21 steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3–6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC50 values being 6.2 and 17.6 μM, respectively, compared to the positive control 5-fluorouracil (6.4 μM).

作 者: Dan Zhao, Ming-Xu Tang, Shan-Shan Su, Xiao-Jie Lu, Yu-Bo Wang, Shao-Fei Chen, Hai-Feng Wang, Gang Chen & Yue-Hu Pe
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学科领域:医学科学 » 药物学 » 天然药物化学
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原文链接:http://www.tandfonline.com/doi/full/10.1080/10286020.2017.1396977
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