首页>>文献首页>>文献正文

Diagnostic and prognostic value of miR-106a in colorectal cancer

haibinhao104 添加于 2017/11/16 11:13:44  568次阅读 | 0次推荐 | 0个评论

We sought to systematically evaluate the diagnostic and prognostic value miR106a in patients with colorectal cancer (CRC). An original study was conducted to explore correlations between tissue miR106a levels and outcomes for 138 patients diagnosed with CRC. To explore the diagnostic performance of miR106a, eligible studies were identified from medical databases from China and abroad. Based on these results, 15 studies (including our original study) were pooled and included in a meta-analyses. The pooled sensitivity, specificity, and diagnostic odds ratios of miR106a were 0.53 (95% confidence interval (CI): 0.49-0.57), 0.85 (95% CI: 0.82-0.88), and 7.22 (95% CI: 3.17-16.44) for diagnosis of CRC, and the area under the curve (AUC) for miR106a when diagnosing CRC was 0.72. Patients with higher expression of tissue miR106a had poor overall survival (pooled hazard ratio (HR): 1.50; 95% CI: 1.02-2.20), but not disease-free survival (pooled HR: 1.03; 95% CI: 0.40-2.65). Overexpression of miR106a may predict superior metastasis-free survival (pooled HR: 0.65; 95% CI: 0.33-1.27), but the effect was not significant in this study (p = 0.21).

作 者:Haibin Hao, Laipeng Liu, Dong Zhang,Chao Wang, Guangfeng Xia, Fuping Zhong, Xiaoyun Hu
期刊名称: Oncotarget
期卷页: 2017 Jan 17 第8卷 第3期 5038–5047页
学科领域:医学科学 » 肿瘤学 » 肿瘤病因
添加人是否为作者:
原文链接:https://www.ncbi.nlm.nih.gov/pubmed/27926519
DOI:
ISBN:
关键词:
备 注:
文献笔记

   
导出选项:

评论 (0 个评论)

Page 1 of 1
<<<[1]>>>

举报 | Archiver | 科学网( 京ICP备07017567 )

GMT+8, 2011-2-15 11:31

Powered by ScienceNet.cn

Copyright © 2007- 科学时报社