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Five balances in the management of rheumatoid arthritis

srzouyzu 添加于 2017/9/12 16:11:32  1347次阅读 | 0次推荐 | 2个评论

Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, then it is impossible to cure completely today and it should be individualized treatment. Immune system is complex. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this Review, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for one year using this strategy, and the management effect is good. This Review argues RA is self-limiting to some extent, good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in controlling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis.

作 者:shengrong zou
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期卷页: 第卷 第期 页
学科领域:医学科学 » 医学免疫学 » 自身免疫性疾病
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原文链接:http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=78695
DOI: 10.4236/jbm.2017.59002
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发表评论人:srzouyzu [2017/9/12 16:12:45] 
类风湿关节炎是常见的慢性自身免疫性关节病。类风湿关节炎的病因复杂,直到今天还不能完全治愈,今后的发展趋势是必须结合类风湿关节炎患者的不同病因进行个体化治疗。
然而人的免疫系统是复杂的,现有的基于还原论的统计方法并不能发现所有的致病风险因素及因素间的复杂交互关系,建立基于复杂网络的类风湿关节炎疾病网络模型对研究病因和治疗方法具有重要的意义。
在本综述中,我们提出了类风湿关节炎治疗和管理中的五个网络平衡调节策略。使用该方法对一例类风湿关节炎患者进行了一年紧密随访,效果良好。本文认为,类风湿关节炎在一定程度上是自限性的,使用五个平衡调节策略进行良好管理将有积极的意义,其中神经内分泌系统和免疫系统之间的平衡是最重要的,白天分泌旺盛的糖皮质激素对控制炎症有重要作用,夜间慢波睡眠中产生的生长激素对消除炎症有重要作用。五个平衡对其他病因引起的关节炎也同样重要。

关键字:类风湿关节炎、自身免疫病、复杂网络、平衡、网络医学
发表评论人:srzouyzu [2017/9/12 16:12:22] 
RA is a chronic inflammatory autoimmune disease, which can cause cartilage and bone damage as well as disability. Early diagnosis and good management are keys to optimal therapeutic success. We have used five balances regulating strategy to follow up the patient with RA, among which the balance between neuroendocrine system and immune system is the most important. It seems that using this strategy could assist rheumatologists in achieving low disease activity or remission in the majority of their patients.
This Review argues that RA is self-limiting to some extent, but the duration of disease will leave sequela with different degrees of joint deformation. Therefore, it is necessary to use this strategy in the RA management early. During the day, glucocorticoid plays an important role in controlling of inflammation, and hu-man growth hormone plays an important role in eliminating inflammation dur-ing the slow-wave sleep at night. Finally, RA and psoriatic arthritis are two of the most prevalent inflammatory rheumatic musculoskeletal diseases. Five bal-ances are also important to other causes of arthritis, such as psoriatic arthritis, reactive arthritis, osteoarthritis, infectious arthritis.
RA disease network model based on complex network is important for the analysis and treatment of disease. But at the present stage the research of complex network theory is not clear enough to describe the relationship between structure and function of complex system [40][41]. Through reviewing literature, this Review has found five important layers of RA complex network. At next step we hope more researchers to participate in "Network Medicine" study to accumulate more cases, constantly improve the RA network model and analyze parameters characteristic and interaction relationship of RA network model. Only common characteristics network model based on the more RA patients improved in the future, could RA be individualized treated.
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