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Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine

zhpd55 添加于 2017/2/19 16:03:20  214次阅读 | 0次推荐 | 5个评论

Ingestion of titanium dioxide (TiO2) nanoparticles from products such as agricultural chemicals, processed food, and nutritional supplements is nearly unavoidable. The gastrointestinal tract serves as a critical interface between the body and the external environment, and is the site of essential nutrient absorption. The goal of this study was to examine the effects of ingesting the 30 nm TiO2 nanoparticles with an in vitro cell culture model of the small intestinal epithelium, and to determine how acute or chronic exposure to nano-TiO2 influences intestinal barrier function, reactive oxygen species generation, proinflammatory signaling, nutrient absorption (iron, zinc, fatty acids), and brush border membrane enzyme function (intestinal alkaline phosphatase). A Caco-2/HT29-MTX cell culture model was exposed to physiologically relevant doses of TiO2 nanoparticles for acute (4 h) or chronic (five days) time periods. Exposure to TiO2 nanoparticles significantly decreased intestinal barrier function following chronic exposure. Reactive oxygen species (ROS) generation, proinflammatory signaling, and intestinal alkaline phosphatase activity all showed increases in response to nano-TiO2. Iron, zinc, and fatty acid transport were significantly decreased following exposure to TiO2 nanoparticles. This is because nanoparticle exposure induced a decrease in absorptive microvilli in the intestinal epithelial cells. Nutrient transporter protein gene expression was also altered, suggesting that cells are working to regulate the transport mechanisms disturbed by nanoparticle ingestion. Overall, these results show that intestinal epithelial cells are affected at a functional level by physiologically relevant exposure to nanoparticles commonly ingested from food.

作 者:Zhongyuan Guo, Nicole J. Martucci, Fabiola Moreno-Olivas, Elad Tako, Gretchen J. Mahler
期刊名称: NanoImpact
期卷页: Available online 18 January 2017 第5卷 第期 70-82页
学科领域:生命科学 » 食品科学 » 食品科学基础
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原文链接:http://www.sciencedirect.com/science/article/pii/S2452074816301185
DOI: 10.1016/j.impact.2017.01.002
ISBN:
关键词: TiO2; Nanoparticles; Ingestion; Small intestine; Nutrient absorption
全文地址: 下载
备 注: The ability of small intestine cells to absorb nutrients and act as a barrier to pathogens is "significantly decreased" after chronic exposure to nanoparticles of titanium dioxide, a common food additive found in everything from chewing gum to bread, according to research from Binghamton University, State University of New York.
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