首页>>文献首页>>文献正文

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

renchunxiao 添加于 2013/2/21 9:55:50  2770次阅读 | 0次推荐 | 0个评论

RIG-I is a critical RNA virus sensor that serves to initiate antiviral innate immunity. However, posttranslational regulation of RIG-I signaling remains to be fully understood. We report here that RNA viruses, but not DNA viruses or bacteria, specifically upregulate lectin family member Siglecg expression in macrophages by RIG-I- or NF-B-dependent mechanisms. Siglec-G-induced recruitment of SHP2 and the E3 ubiquitin ligase c-Cbl to RIG-I leads to RIG-I degradation via K48-linked ubiquitination at Lys813 by c-Cbl. By increasing type I interferon production, targeted inactivation of Siglecg protects mice against lethal RNA virus infection. Taken together, our data reveal a negative feedback loop of RIG-I signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses with implication in antiviral applications. These findings also provide insights into the functions and crosstalk of Siglec-G, a known adaptive response regulator, in innate immunity.

作 者:Weilin Chen, Chaofeng Han, Bin Xie, Xiang Hu, Qian Yu, Liyun Shi, Qingqing Wang, Dongling Li, Jianli Wang, Pan Zheng, Yang Liu, Xuetao Cao
期刊名称: cell
期卷页: 第卷 第期 页
学科领域:生命科学 » 免疫学 » 免疫生物学
添加人是否为作者:
原文链接:http://www.cell.com/abstract/S0092-8674(13)00017-2
DOI:
ISBN:
关键词:
备 注:
文献笔记

   
导出选项:

评论 (0 个评论)

Page 1 of 1
<<<[1]>>>

举报 | Archiver | 科学网( 京ICP备07017567 )

GMT+8, 2011-2-15 11:31

Powered by ScienceNet.cn

Copyright © 2007- 科学时报社