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L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia

SprMorn 添加于 2013/1/24 14:05:51  2318次阅读 | 0次推荐 | 2个评论

Bacteria, exemplified by enteropathogenic Escherichia coli (E. coli), rely on elaborate acid resistance systems to survive acidic environment (such as the stomach). Comprehensive understanding of bacterial acid resistance is important for prevention and clinical treatment. In this study, we report a previously uncharacterized type of acid resistance system in E. coli that relies on L-glutamine (Gln), one of the most abundant food-borne free amino acids. Upon uptake into E. coli, Gln is converted to L-glutamate (Glu) by the acid-activated glutaminase YbaS, with concomitant release of gaseous ammonia. The free ammonia neutralizes proton, resulting in elevated intracellular pH under acidic environment. We show that YbaS and the amino acid antiporter GadC, which exchanges extracellular Gln with intracellular Glu, together constitute an acid resistance system that is sufficient for E. coli survival under extremely acidic environment.

作 者:Peilong Lu, Dan Ma, Yuling Chen, Yingying Guo, Guo-Qiang Chen, Haiteng Deng, Yigong Shi
期刊名称: Cell Research
期卷页: 2013-01-22 第卷 第期 ~页
学科领域:生命科学 » 微生物学 » 微生物生理与生物化学
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原文链接:http://www.nature.com/cr/journal/vaop/ncurrent/full/cr201313a.html
DOI: doi:10.1038/cr.2013.13
ISBN: 1001-0602
关键词: CR, cancer, immunology, neurodegeneration, apoptosis, cell death, cell growth, differentiation
相关报道: http://paper.sciencenet.cn/htmlpaper/20131241472737127660.shtm
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发表评论人: [2013/1/24 14:13:06] 
Received 4 December 2012; Revised 12 December 2012; Accepted 13 December 2012
真快啊
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