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Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer.

AmandaPisces 添加于 2013/1/7 15:06:48  1051次阅读 | 0次推荐 | 0个评论

To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, including up to 5,358 cases and 5,922 controls. We identified four SNPs with association P values of 8.58 × 10(-7) to 3.77 × 10(-10) in the combined analysis of all east Asian samples. Three of the four were replicated in a study conducted in 26,060 individuals of European descent, with combined P values of 1.22 × 10(-10) for rs647161 (5q31.1), 6.64 × 10(-9) for rs2423279 (20p12.3) and 3.06 × 10(-8) for rs10774214 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both east Asian and European-ancestry populations. This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC.

作 者:Jia Wei-Hua WH,Zhang Ben B,Matsuo Keitaro K,Shin Aesun A,Xiang Yong-Bing YB,Jee Sun Ha SH,Kim Dong-Hyun DH,Ren Zefang Z,Cai Qiuyin Q,Long Jirong J,Shi Jiajun J,Wen Wanqing W,Yang Gong G,Delahanty Ryan J RJ,Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)Colon Cancer Family Registry (CCFR)Ji Bu-Tian BT,Pan Zhi-Zhong ZZ,Matsuda Fumihiko F,Gao Yu-Tang YT,Oh Jae Hwan JH,Ahn Yoon-Ok YO,Park Eun Jung EJ,Li Hong-Lan HL,Park Ji Won JW,Jo Ja
期刊名称: Nature genetics
期卷页: 2012Dec23 第卷 第期 页
学科领域:医学科学 » 肿瘤学 » 肿瘤病因
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原文链接:http://www.ncbi.nlm.nih.gov/pubmed/23263487
DOI: 10.1038/ng.2505
ISBN: 1546-1718
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相关报道: http://paper.sciencenet.cn/htmlpaper/2013171627584527373.shtm
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