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Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis

zhangxia111 添加于 2012/12/28 16:19:45  1175次阅读 | 0次推荐 | 0个评论

Ivorenolide A (1), a novel 18-membered macrolide featuring conjugated acetylenic bonds and five chiral centers, was isolated from Khaya ivorensis. The structure of 1 was fully determined by spectroscopic analysis, single-crystal X-ray diffraction, and bioinspired total synthesis. Both compound 1 and its synthetic enantiomer 2 showed potent and selective immunosuppressive activity.

作 者:Bo Zhang , Yao Wang , Sheng-Ping Yang , Yu Zhou , Wen-Bin Wu , Wei Tang , Jian-Ping Zuo , Ying Li , and Jian-Min Yue
期刊名称: American Chemical Society
期卷页: 第卷 第期 ~页
学科领域:生命科学 » 植物学 » 植物生理与生化
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原文链接:http://pubs.acs.org/doi/abs/10.1021/ja310482z?prevSearch=Ivorenolide+A
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相关报道: http://paper.sciencenet.cn/htmlpaper/201212311040925927396.shtm
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