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Direct Imaging of DNA Fibers: The Visage of Double Helix

dankan 添加于 2012/12/11 13:40:12  1043次阅读 | 0次推荐 | 0个评论

Direct imaging becomes important when the knowledge at few/single molecule level is requested and where the diffraction does not allow to get structural and functional information. Here we report on the direct imaging of double stranded (ds) λ-DNA in the A conformation, obtained by combining a novel sample preparation method based on super hydrophobic DNA molecules self-aggregation process with transmission electron microscopy (TEM). The experimental breakthrough is the production of robust and highly ordered paired DNA nanofibers that allowed its direct TEM imaging and the double helix structure revealing.

作 者:Francesco Gentile,Manola Moretti,Tania Limongi,Andrea Falqui,Giovanni Bertoni,Alice Scarpellini,Stefania Santoriello,Luca Maragliano,Remo Proietti Zaccaria,Enzo di Fabrizio,
期刊名称: Nano Letters
期卷页: 第卷 第期 ~页
学科领域:信息科学 » 电子学与信息系统 » 生物电子学与生物信息处理
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原文链接:http://pubs.acs.org/doi/abs/10.1021/nl3039162
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关键词: DNA bundles direct imaging, transmission electron microscopy, superhydrophobic surface, nanofabricated micropillars, molecular dynamics simulations
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