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Mouse Embryonic Head as a Site for Hematopoietic Stem Cell Development

zhangxia111 添加于 2012/11/5 14:28:34  777次阅读 | 0次推荐 | 0个评论

In the mouse embryo, the aorta-gonad-mesonephros (AGM) region is considered to be the sole location for intraembryonic emergence of hematopoietic stem cells (HSCs). Here we report that, in parallel to the AGM region, the E10.5–E11.5 mouse head harbors bona fide HSCs, as defined by long-term, high-level, multilineage reconstitution and self-renewal capacity in adult recipients, before HSCs enter the circulation. The presence of hemogenesis in the midgestation head is indicated by the appearance of intravascular cluster cells and the blood-forming capacity of a sorted endothelial cell population. In addition, lineage tracing via an inducible VE-cadherin-Cre transgene demonstrates the hemogenic capacity of head endothelium. Most importantly, a spatially restricted lineage labeling system reveals the physiological contribution of cerebrovascular endothelium to postnatal HSCs and multilineage hematopoiesis. We conclude that the mouse embryonic head is a previously unappreciated site for HSC emergence within the developing embryo.

作 者:Zhuan Li, Yu Lan, Wenyan He, Dongbo Chen, Jun Wang, Fan Zhou, Yu Wang, Huayan Sun, Xianda Chen, Chunhong Xu, Sha Li, Yakun Pang, Guangzhou Zhang, Liping Yang, Lingling Zhu, Ming Fan, Aijia Shang, Zhenyu Ju, Lingfei Luo, Yuqiang Ding, Wei Guo, Weiping Yuan, Xiao Yang, Bing Liu
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学科领域:生命科学 » 细胞生物学 » 细胞生长与分裂
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原文链接:http://www.cell.com/cell-stem-cell/abstract/S1934-5909(12)00419-5
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相关报道: http://paper.sciencenet.cn/htmlpaper/2012111314374246126389.shtm
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