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Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

zhangxia111 添加于 2012/11/2 13:55:15  823次阅读 | 0次推荐 | 0个评论

Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10−4, N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.

作 者:Ming Li, Yi Wang, Xue-bin Zheng AFFILIATIONS Human Genetics, Genome Institute of Singapore, A*STAR, Singapore , Masashi Ikeda, Nakao Iwata, Xiong-jian Luo, Siow-Ann Chong, Jimmy Lee, Marcella Rietschel, Fengyu Zhang, Bertram Müller-Myhsok, Sven Cichon, Daniel R. Weinberger, Manuel Mattheisen, Thomas G. Schulze, Nicholas G. Martin, Philip B. Mitchell, Peter R. Schofield, Jian-jun Liu, Bing Su, MooDS Consortium
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学科领域:生命科学 » 遗传学与生物信息学 » 人类遗传学
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原文链接:http://www.schres-journal.com/article/S0920-9964(12)00580-4/abstract
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