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A Mouse Model of Salmonella Typhi Infection

zhangxia111 添加于 2012/10/29 14:31:31  1473次阅读 | 0次推荐 | 5个评论

Salmonella spp. are gram-negative flagellated bacteria that can cause food- and waterborne gastroenteritis and typhoid fever in humans. We now report that flagellin from Salmonella spp. is recognized in mouse intestine by Toll-like receptor 11 (TLR11). Absence of TLR11 renders mice more susceptible to infection by S. Typhimurium, with increased dissemination of the bacteria and enhanced lethality. Unlike S. Typhimurium, S. Typhi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice. TLR11 is expressed in mice, but not in humans, and remarkably, we find that tlr11−/− mice are efficiently infected with orally administered S. Typhi. We also find that tlr11−/− mice can be immunized against S. Typhi. Therefore, tlr11−/− mice represent a small-animal model for the study of the immune response to S. Typhi and for the development of vaccines against this important human pathogen.

作 者:Ramkumar Mathur, Hyunju Oh, Dekai Zhang, Sung-Gyoo Park, Jin Seo, Alicia Koblansky, Matthew S. Hayden, Sankar Ghosh
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期卷页: 第卷 第期 页
学科领域:医学科学 » 神经系统和精神疾病 » 躯体感觉、疼痛与镇痛
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原文链接:http://www.cell.com/abstract/S0092-8674(12)01176-2
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