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Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity

renchunxiao 添加于 2012/6/28 11:13:41  1802次阅读 | 1次推荐 | 4个评论

Tissue damage induced by ionizing radiation in the hematopoietic and gastrointestinal systems is the major cause of lethality in radiological emergency scenarios and underlies some deleterious side effects in patients undergoing radiation therapy1, 2. The identification of target-specific interventions that confer radiomitigating activity is an unmet challenge. Here we identify…

作 者:Hartmut Geiger, Snehalata A Pawar, Edward J Kerschen, Kalpana J Nattamai, Irene Hernandez, Hai Po H Liang, Jose Á Fernández, Jose A Cancelas, Marnie A Ryan, Olga Kustikova, Axel Schambach, Qiang Fu, Junru Wang, Louis M Fink, Karl-Uwe Petersen, Daohong Zhou, John H Griffin, Christopher Baum, Hartmut Weiler & Martin Hauer-Jensen
期刊名称: nature medicine
期卷页: 第卷 第期 ~页
学科领域:医学科学 » 医学免疫学 » 免疫器官/组织/细胞的发育分化异常
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原文链接:http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2813.html
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