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Widespread RNA and DNA Sequence Differences in the Human Transcriptome

renchunxiao 添加于 2011/5/27 11:19:12  2843次阅读 | 1次推荐 | 0个评论

he transmission of information from DNA to RNA is a critical process. We compared RNA sequences from human B cells of 27 individuals to the corresponding DNA sequences from the same individuals and uncovered more than 10,000 exonic sites where the RNA sequences do not match that of the DNA. All 12 possible categories of discordances were observed. These differences were nonrandom, as many sites were found in multiple individuals and in different cell types, including primary skin cells and brain tissues. Using mass spectrometry, we detected peptides that are translated from the discordant RNA sequences and thus do not correspond exactly to the DNA sequences. These widespread RNA-DNA differences in the human transcriptome provide a yet-unexplored aspect of genome variation.

作 者:Li, Mingyao; Wang, Isabel X.; Li, Yun; Bruzel, Alan; Richards, Allison L.; Toung, Jonathan M.; Cheung, Vivian G.
期刊名称: Science
期卷页: 第卷 第期 ~页
学科领域:生命科学 » 遗传学与生物信息学 » 人类遗传学
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原文链接:http://www.sciencemag.org/content/early/2011/05/18/science.1207018
DOI: 10.1126/science.1207018
ISBN: 0036-8075
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相关报道: http://paper.sciencenet.cn/htmlpaper/201152712381735817145.shtm
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